Web aplikacija za pretraživanje baze biološki značajnih metala

undergraduate thesis

• Title (english): A web application for searching biologicaly relevant metals database
• Author: Antonio Mišić
• Mentor: Krešimir Križanović (mentor)
• Committee member: Krešimir Križanović (predsjednik povjerenstva)
• Committee member: Josipa Lipovac (član povjerenstva)
• Committee member: Filip Tomas (član povjerenstva)
• Granter: University of Zagreb; Faculty of Electrical Engineering and Computing; Zagreb
• Defense date and country: 2023-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Computing

Abstract

Ovaj rad donosi opis sustava za analizu biomolekula, kroz pretraživanja i statistike.
Arhitektura sustava sastoji se od 3 dijela : web aplikacija, parser podataka , baza podataka.
Prije razvitka web aplikacije, prvi na red su došli parser podataka i baza podataka.
Sustav koristi PostgreSQL bazu podataka, sa strukturom preuzetom iz rada Tus-a. Baza sadrži informacije o strukturama, lancima, ligandima i atomima, te udaljenostima između atoma, popraćeni s geometrijskim strukturama i kutovima.
Parser podataka je dio sustava, koji puni bazu podataka tim potrebnim informacijama.
Ključni dio sustava je web aplikacija implementiran je kao dva pod sustava : Korisničko sučelje (engl. Fronted) i Pozadinska strana (engl. Backend).
Korisničko sučelje je implementirano u razvojnom okviru Angular 15, dok je Pozadinska strana implantirana u razvojnom okviru .Net.
Kroz interakciju s web aplikacijom, korisnik može saznati razne informacije o metalima i njihovim međudjelovanjem s ligandima.
Takvi rezultati dostupni su nakon ispunjavanja forme, odnosno parametara koji će biti uključeni u izračun statistika.
Rezultati statistika su dostupni u tabličnom formatu.
Sustav u usporedbi s BioMe sustavom nije bolji, ali je ponovno upogonio ideju sustava Alena Rakipovića u duhu novih tehnologija.
Mane ovog sustava su nepouzdanost rezultata statistika i nemogućnost dohvaćanja svih statistika, jer nisu sve implementirane.

Sustav nije dostupan na internetu, no njegov kod potreban za pokretanje bit će dostupan na ovome linku, osobnog GitHub računa.

Abstract (english)

This paper presents a description of a biomolecular analysis system that utilizes search and statistical techniques. The system architecture consists of three components: a web application, a data parser, and a database. Prior to developing the web application, the data parser and database were implemented. The system utilizes a PostgreSQL database with a structure adapted from the Tus paper, containing information about structures, chains, ligands, atoms, as well as distances between atoms accompanied by geometric structures and angles.

The data parser is an integral part of the system, responsible for populating the database with the necessary information. The key component of the system is the web application, which is implemented as two subsystems: the Frontend, developed using the Angular 15 framework, and the Backend, developed using the .Net framework. Through interaction with the web application, users can obtain various information about metals and their interactions with ligands.

Such results are available after filling out a form with parameters that will be used for statistical calculations. The statistical results are presented in a tabular format. While the system does not outperform the BioMe system, it does revive the concept initially proposed by Alen Rakipović, incorporating the latest technologies.

The limitations of this system include the unreliability of the statistical results and the inability to retrieve all statistics, as not all of them have been implemented. Although the system is not accessible online, the code necessary for its deployment will be made available on my personal GitHub account through the provided link.

• Keywords: biomolekule; metali; ligandi; nukleinske kiseline; frontend; backend; statistike
• Keywords (english): BioMoleculs; metals; lingads; nucleis acids; frontend; backend; statistics
• Language: croatian
• URN:NBN: urn:nbn:hr:168:012839
• Study programme: Title: Computing; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka računarstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka računarstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2023-10-11 09:52:04