Simulacija modela rasta epitelnog tkiva

undergraduate thesis

• Title (english): Simulation of Epithelial Tissue Growth
• Author: Lovro Nuić
• Mentor: Željka Mihajlović (mentor)
• Committee member: Željka Mihajlović (predsjednik povjerenstva)
• Committee member: Petar Paradžik (član povjerenstva)
• Committee member: Juraj Fulir (član povjerenstva)
• Granter: University of Zagreb; Faculty of Electrical Engineering and Computing; Zagreb
• Defense date and country: 2021-07-01, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Computing

Abstract

Radi boljeg razumijevanja rast tkiva često modeliramo jednoslojni epitel, čiji je jedan od predstavnika Madin-Darby Canine Kidney (MDCK) tkivo. U ovom završnom radu razvijen je paralelni algoritam izgradnje Voronoijeva dijagrama skupova. Implementirani algoritam primijenjen je na jezgru oblika elipse u dvočestičnom modelu stanice. Simulaciji rasta MDCK tkiva izvedena je disipativnom dinamikom čestica uz optimizaciju strukture stanice Lloydovim algoritmom. Nadalje, provedeno je učenje U-Net konvolucijske neuronske mreže za segmentaciju jezgri stanica tkiva.

Abstract (english)

In order to better understand tissue growth, a single-layer epithelium, represented by Madin-Darby Canine Kidney (MDCK) tissue, is often modeled. In this final paper, a parallel algorithm for constructing the Set Voronoi tessellation is developed. The implemented algorithm is applied to an ellipse-shaped nucleus in a two-particle cell model. Simulation of MDCK tissue growth was performed by dissipative particle dynamics with optimization of cell structure by Lloyd's algorithm. Furthermore, the U-Net convolutional neural network is employed to predict tissue cell nucleus segmentation.

• Keywords: Voronoijev dijagram skupova; epitelna tkiva; segmentacija jezgri stanica; disipativna dinamika čestica; GPGPU programiranje
• Keywords (english): Set Voronoi Tessellation (SVT); epithelial tissue; nuclei segmentation; DPD simulation; GPGPU programming
• Language: croatian
• URN:NBN: urn:nbn:hr:168:506401
• Study programme: Title: Computing; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka računarstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka računarstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Created on: 2023-01-14 21:19:17